Jill Leutgeb

jleutgeb

The main goal of our research is to describe the neural basis of memory formation and retrieval at the systems level, and to determine how the various subregions of the medial temporal lobe, including the hippocampus, contribute to memory processing. We are interested in what type of information the distinct populations of medial temporal lobe neurons convey and how coordinated neuronal activity and synaptic plasticity in these networks contribute to the distinct computations essential for the encoding of episodic memory. Our lab is particularly interested in understanding the network computations of neuronal populations in the first processing stages of the hippocampus, namely the CA3 and dentate gyrus. The anatomically distinct arrangement of this brain region has inspired many computational models that have hypothesized their distinct roles in memory formation. While behavioral studies have supported many of these predictions, very little is known about how the neural networks in the CA3-dentate network perform these functions, and what contribution the various cell populations within the network contribute to the encoding necessary for memory formation. To address these questions we record simultaneously from large groups of neurons (up to 100) in anatomically and functionally related circuits in the mammalian brain during learning. Our lab combines high-density electrophysiology, behavioral testing, theoretical modeling, and pharmacological and molecular manipulations as a multidisciplinary approach to understanding the neural basis of cognition. Understanding the contribution of the various cell populations within the CA3-dentate network to memory formation will have considerable importance for systems neuroscience and also for translational research since the dentate gyrus is among the first structures in the brain to show decreased neuronal activity in Alzheimer’s disease. In addition, diverse changes in the dentate network and the activity patterns of its neurons have also been linked to the onset of temporal lobe epilepsy. We are interested in understanding how the structural reorganization of memory circuits during disease impairs their contribution to memory and results in the profound memory impairments reported in medial temporal lobe epilepsy. The various phases of MTL epilepsy are associated with distinct memory impairments, and we seek to determine their underlying network mechanisms.

Jill Leutgeb is at UC San Diego | Lab Website