The main focus of my lab is to study the neural basis of episodic memory, the memory for personal experiences. To investigate this important issue, we use a combination of temporary brain inactivation and high-density electrophysiological recording techniques in the rat. We are particularly interested in elucidating the role of the hippocampus, parahippocampal region, and prefrontal cortex, as well as their functional interactions. We have shown that individual neurons in the hippocampus (Fortin et al., 2010) and prefrontal cortex (Allen et al., 2011) are highly engaged as animals perform a novel non-spatial sequence memory task we developed. Importantly, our findings support our hypothesis that the hippocampus and prefrontal cortex make fundamentally distinct contributions to the memory for sequences of events, and have also shed light on the dynamic nature of the functional relationship between the two structures.